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Chemical Structure : LOC14
CAS No.: 877963-94-5
Catalog No.: PC-70321Not For Human Use, Lab Use Only.
LOC14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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LOC14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM.
LOC14-induced oxidation of PDI has a neuroprotective effect not only in cell culture, but also in corticostriatal brain slice cultures.
LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.
| M.Wt | 317.41 | |
| Formula | C16H19N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
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1. Kaplan A, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52.
2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50.
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