LOXO-435 (LY3866288)

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Chemical Structure : LOXO-435

Catalog No.: PC-25666Not For Human Use, Lab Use Only.

LOXO-435 (LY3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LOXO-435 (LY3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations.

Physicochemical Properties

M.Wt	496.93
Formula	C23H22ClFN8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(4-(3-chloro-4-(1-(5-fluoropyridin-2-yl)-2-hydroxyethoxy)pyrazolo[1,5-a]pyridin-6-yl)-5-methyl-1H-1,2,3-triazol-1-yl)piperidine-1-carbonitrile

References

1. Gopa Iyer, et al. Cancer Res (2023) 83 (8_Supplement): CT119.

2. Patent WO2022187443 A1.

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