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LOXO-435

Chemical Structure : LOXO-435

CAS No.: 2833703-74-3

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LOXO-435 (Vepugratinib, LY3866288, LOXO435, LY-3866288)

Catalog No.: PC-25666Not For Human Use, Lab Use Only.

Vepugratinib (LOXO-435, LY-3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Vepugratinib (LOXO-435, LY-3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations.

    Physicochemical Properties

    M.Wt 496.93
    Formula C23H22ClFN8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(4-(3-chloro-4-(1-(5-fluoropyridin-2-yl)-2-hydroxyethoxy)pyrazolo[1,5-a]pyridin-6-yl)-5-methyl-1H-1,2,3-triazol-1-yl)piperidine-1-carbonitrile

    References

    1. Gopa Iyer, et al. Cancer Res (2023) 83 (8_Supplement): CT119.

    2. Patent WO2022187443 A1.

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