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LP-403812

Chemical Structure : LP-403812

CAS No.: 1142050-84-7

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LP-403812 (LP403812)

Catalog No.: PC-21227Not For Human Use, Lab Use Only.

LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT.
LP-403812 shows no significant inhibition of glycine and dopamine transporters at concentrations up to 10 uM.
LP-403812 inhibits proline transporter activity of mouse brain synaptosomes with the same potency.

Physicochemical Properties

M.Wt 494.66
Formula C26H34N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, N-[1-(1,1-dimethylethyl)-3-[[(2S)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrazolo[3,4-d]thiazol-5-yl]-4-methyl-

References

1. Xuan-Chuan Yu, et al. Neurosci Lett. 2009 Feb 27;451(3):212-6.

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