LP-856866 | ACSL5 inhibitor | Probechem Biochemicals

Chemical Structure : LP-856866

LP-856866 (ACSL5i)

Catalog No.: PC-25994Not For Human Use, Lab Use Only.

LP-856866 (ACSL5i) is a potent, selective inhibitor of Acyl-CoA Synthetase 5 (ACSL5) with IC50 of 4 nM and 8 nM for huamn and mouse ACSL5 in acyl-CoA synthetase (ACS) assays, highly selective against ACSL3.

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Biological Activity

LP-856866 (ACSL5i) is a potent, selective inhibitor of Acyl-CoA Synthetase 5 (ACSL5) with IC50 of 4 nM and 8 nM for huamn and mouse ACSL5 in acyl-CoA synthetase (ACS) assays, highly selective against ACSL3.

Physicochemical Properties

M.Wt	521.55
Formula	C26H26F3NO5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(tert-butylsulfonyl)-4-(1-(3-phenoxyphenyl)ethoxy)-3-(trifluoromethyl)benzamide

References

1. Powell DR, et al. J Endocr Soc. 2025 Nov 28;10(2):bvaf196.

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LP-856866 (ACSL5i)

Biological Activity

Physicochemical Properties

References

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