Chemical Structure : LPHN2 inhibitor D11
CAS No.:
371232-48-3
LPHN2 inhibitor D11
(Latrophilin 2 inhibitor)
Catalog No.: PC-24318Not For Human Use, Lab Use Only.
LPHN2 inhibitor D11 is a reversible and selective inhibitor of mechanosensitive GPCR latrophilin 2 (LPHN2, ADGRL2), inhibits mechanosensitivity of LPHN2 in HEK293 cells with IC50 of 20 nM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LPHN2 inhibitor D11 is a reversible and selective inhibitor of mechanosensitive GPCR latrophilin 2 (LPHN2, ADGRL2), inhibits mechanosensitivity of LPHN2 in HEK293 cells with IC50 of 20 nM.
D11 inhibited 3 pN force-induced LPHN2 activation in LPHN2-overexpressing HEK293 cells with IC50 of 39.88 nM.
D11 has no detectable effects on either the force-induced or agonist-induced activation of other adhesion GPCRs in the heterologous HEK293 overexpression system.
D11 dose-dependently inhibited MET currents in utricular hair cells with EC50 of 25 nM.
D11 (50 nM) abrogated the residual normal-polarity MET current in the BAPTA-treated utricular hair cells derived from the Pou4f3-CreER+/−;Lphn2+/+ mice.
Physicochemical Properties
|
M.Wt
|
487.88
|
|
Formula
|
C20H17ClF3N3O4S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(2-chloro-5-(trifluoromethyl)phenyl)-2-((2,5-dimethoxyphenyl)amino)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide
|
References
1. Jeon MS, et al. Cancer Res Treat. 2016 Apr;48(2):676-86.
2. Yang Z, et al. Cell Res. 2025 Feb 18. doi: 10.1038/s41422-025-01075-x.
3. Zhao Yang, et al. bioRxiv https://doi.org/10.1101/2023.1110.1124.563883 (2024).
Contact Us
sales@probechem.com
