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LQB-118

Chemical Structure : LQB-118

CAS No.: 1219104-20-7

LQB-118 (LQB 118, LQB118)

Catalog No.: PC-60560Not For Human Use, Lab Use Only.

LQB-118 is an orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo.

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    Biological Activity

    LQB-118 is an orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo.
    LQB-118 induces apoptosis in cells derived from chronic myeloid leukemia patients, exhibiting multifactorial drug resistance phenotype such as P-glycoprotein, MRP1 and p53 overexpression.
    LQB-118 shows activity active against intracellular amastigotes of L. amazonensis with IC50 of 1.4 uM, inhibits parasite growth in L.amazonensis-infected BALB/c mice.

    Physicochemical Properties

    M.Wt 304.3
    Formula C19H12O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (7aS,12aS)-7,7a-dihydro-5H-benzo[g]benzofuro[3,2-c]chromene-5,13(12aH)-dione

    References

    1. Maia RC, et al. Invest New Drugs. 2011 Dec;29(6):1143-55.

    2. de Souza Reis FR, et al. Anticancer Agents Med Chem. 2013 Feb;13(2):341-51.

    3. Martino T, et al. Bioorg Med Chem. 2014 Jun 15;22(12):3115-22.

    4. Martino T, et al. Prostate. 2018 Feb;78(2):140-151.

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