Catalog No.: PC-27294Not For Human Use, Lab Use Only.
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation.
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation.
LRPPRC inhibitor 3o downregulates downstream OXPHOS subunits and ATP synthase, elicits broad antiproliferative effects in refractory and drug-resistant A549, BXPC-3, and NCI-H1975 cells (IC50=0.27-1.39 uM).
LRPPRC inhibitor 3o achieved tumor growth inhibition (TGI) rates of 73 and 49% with favorable safety profiles in PC9 and HCT116 xenografts.
