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LSD1-IN-11p

Chemical Structure : LSD1-IN-11p

CAS No.: 2101951-67-9

LSD1-IN-11p

Catalog No.: PC-62840Not For Human Use, Lab Use Only.

LSD1-IN-11p is a potent, reversible LSD1 inhibitor with IC50/Kd of 79/21 nM.

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    Biological Activity

    LSD1-IN-11p is a potent, reversible LSD1 inhibitor with IC50/Kd of 79/21 nM.
    LSD1-IN-11p upregulates the expression of the surrogate cellular biomarker CD86 (IC50=0.52 uM).
    LSD1-IN-11p has moderate oral bioavailability in mice (F%=38%).

    Physicochemical Properties

    M.Wt 420.473
    Formula C22H24N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-4-(3-(3-aminopiperidine-1-carbonyl)-5-((3-ethylisoxazol-5-yl)methoxy)-1H-pyrazol-1-yl)benzonitrile

    References

    1. Mould DP, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3190-3195.

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