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LSD1-IN-32

Chemical Structure : LSD1-IN-32

CAS No.: 2137044-49-4

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LSD1-IN-32

Catalog No.: PC-61732Not For Human Use, Lab Use Only.

LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM.
    LSD1-IN-32 display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690.
    LSD1-IN-32 shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.

    Physicochemical Properties

    M.Wt 422.504
    Formula C24H27FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[[2-(2,7-Diazaspiro[3.5]nonan-7-yl)-2-oxo-ethyl]-[(3-fluoro-4-methoxy-phenyl)methyl]amino]benzonitrile

    References

    1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999.

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