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Chemical Structure : LSD1-IN-32
Catalog No.: PC-61732Not For Human Use, Lab Use Only.
LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM.
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LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM.
LSD1-IN-32 display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690.
LSD1-IN-32 shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.
| M.Wt | 422.504 | |
| Formula | C24H27FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999.
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