Catalog No.: PC-61644Not For Human Use, Lab Use Only.
LSD1 inhibitor-1 is a bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 uM in vitro.
LSD1 inhibitor-1 is a bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 uM in vitro.
LSD1 inhibitor-1 significantly increases H3K4me1 and H3K4me2 dose-dependently from 0.25 uM to 10 uM, without affecting global H3K9me2 in HCT116 human colon carcinoma cells.
LSD1 inhibitor-1 induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
