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LSD1 inhibitor 24

Chemical Structure : LSD1 inhibitor 24

CAS No.: 1853269-07-4

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LSD1 inhibitor 24

Catalog No.: PC-35794Not For Human Use, Lab Use Only.

LSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM, induces CD11b expression in THP-1 cells with EC50 of 8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM, induces CD11b expression in THP-1 cells with EC50 of 8 nM.
    LSD1 inhibitor 24 demonstrates attenuating the hERG inhibition and improving oral bioavailability.

    Physicochemical Properties

    M.Wt 505.982
    Formula C26H25ClFN7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(1-(3-chloro-2-methyl-2H-indazol-5-yl)-5-methyl-4-(3-(methylamino)piperidine-1-carbonyl)-1H-imidazol-2-yl)-2-fluorobenzonitrile

    References

    1. Nie Z, et al. Bioorg Med Chem Lett. 2018 Nov 3. pii: S0960-894X(18)30855-2.

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