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LUF5834

Chemical Structure : LUF5834

CAS No.: 333962-91-7

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LUF5834 (LUF-5834)

Catalog No.: PC-22361Not For Human Use, Lab Use Only.

LUF5834 is a potent, selective, non-adenosine adenosine A1 receptor adenosine receptor (A2BR) partial agonist with EC50 of 12 nM (hA2B), 45-fold selective over hA3, also shows high affinity with Ki of 2.6 nM and 28 nM for hA1 and hA2A, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LUF5834 is a potent, selective, non-adenosine adenosine A1 receptor adenosine receptor (A2BR) partial agonist with EC50 of 12 nM (hA2B), 45-fold selective over hA3.
LUF5834 also shows high affinity with Ki of 2.6 nM and 28 nM for hA1 and hA2A, respectively.

Physicochemical Properties

M.Wt 348.38
Formula C17H12N6OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile

References

1. Beukers MW, et al. J Med Chem. 2004 Jul 15;47(15):3707-9.

2. Urmaliya VB, et al. J Cardiovasc Pharmacol. 2009 May;53(5):424-33.

3. Lane JR, et al. Biochem Pharmacol. 2010 Oct 15;80(8):1180-9.

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