LX-191 | GLS1 inhibitor | Probechem Biochemicals

Chemical Structure : LX-191

LX-191 (LX191)

Catalog No.: PC-26396Not For Human Use, Lab Use Only.

LX-191 is a small molecule glutaminase-1 (GLS1) inhibitor with IC50 of 15.17 uM, shows potent antiproliferative activity (A549 IC50=1.56 uM; HCT116 IC50=4.39 uM).

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Biological Activity

LX-191 is a small molecule glutaminase-1 (GLS1) inhibitor with IC50 of 15.17 uM, shows potent antiproliferative activity (A549 IC50=1.56 uM; HCT116 IC50=4.39 uM).
LX-191 LX-191 attenuated glutamine metabolism while concurrently suppressing signal transducer and activator of transcription 3 (STAT3) and mammalian target of rapamycin (mTOR) signaling, leading to G1 phase cell cycle arrest and induction of autophagy.
LX-191 achieved 50.3% tumor growth inhibition at 10 mg/kg, outperforming CB-839 (21.6%) under identical conditions in A549 xenografts

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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LX-191 (LX191)

Biological Activity

Physicochemical Properties

References

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