Chemical Structure : LXG6403
CAS No.:
315705-04-5
LXG6403
(LXG-6403)
Catalog No.: PC-22844Not For Human Use, Lab Use Only.
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1.
LXG6403 inhibits cellular LOX activity with IC50 values of 1.3 μM, 1.43 μM, 4.14 μM, and 3.0 μM in MDA-MB-231, HCC143, Hs-578-T, and HCC1937 cells.
LXG6403 enhances chemoresponse in 3D cultures of TNBC cell lines and PDX organoids.
LXG6403 diminishes collagen crosslinking/deposition and increases drug penetration in 3D culture, inhibiting FAK signaling and potentiating ROS/DNA damage axis.
LXG6403 rewires collagen architecture/signaling, overcomes doxorubicin resistance in chemoresistant TNBC PDXs in vivo.
Physicochemical Properties
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M.Wt
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345.44
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Formula
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C15H15N5OS2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[4-[[4-(2-amino-4-methyl-thiazol-5-yl)thiazol-2-yl]amino]phenyl]acetamide
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References
1. Cetin M, et al. Cell Chem Biol. 2024 Jul 9:S2451-9456(24)00273-3.
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