Catalog No.: PC-22844Not For Human Use, Lab Use Only.
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1.
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1.
LXG6403 inhibits cellular LOX activity with IC50 values of 1.3 μM, 1.43 μM, 4.14 μM, and 3.0 μM in MDA-MB-231, HCC143, Hs-578-T, and HCC1937 cells.
LXG6403 enhances chemoresponse in 3D cultures of TNBC cell lines and PDX organoids.
LXG6403 diminishes collagen crosslinking/deposition and increases drug penetration in 3D culture, inhibiting FAK signaling and potentiating ROS/DNA damage axis.
LXG6403 rewires collagen architecture/signaling, overcomes doxorubicin resistance in chemoresistant TNBC PDXs in vivo.
