Chemical Structure : LXQ-87
CAS No.:
2524718-73-6
LXQ-87
(LXQ87)
Catalog No.: PC-27109Not For Human Use, Lab Use Only.
LXQ-87 is a selective, orally active, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B/PTPN1) with IC50 of 1.06 uM, displays excellent selectivity over TCPTP and SHP-2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LXQ-87 is a selective, orally active, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B/PTPN1) with IC50 of 1.06 uM, displays excellent selectivity over TCPTP and SHP-2.
educes the fasting blood glucose level and improves glucose tolerance and dyslipidemia in BKS db/db mice suffering from T2DM.
LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake by directly binding to intracellular PTP1B.
LXQ-87 exhibits potent antiproliferative effects across a range of cancer cell lines.
LXQ-87 initiates intrinsic mitochondrial apoptosis, causes G0/G1 phase arrest through decreased Cyclin D1/CDK4/6/c-Myc expression, curbs cell migration, and raises reactive oxygen species (ROS) levels, LXQ-87 also reduces STAT3 phosphorylation.
Physicochemical Properties
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M.Wt
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534.20
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Formula
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C23H18Br2O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(2,3-dibromo-4,5-dihydroxyphenyl)-1-(4-(4-ethoxyphenoxy)phenyl)prop-2-en-1-one
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References
1. Gao C, et al. Eur J Med Chem. 2025 Jan 15;282:117053.
2. Xu F, et al. Bioorg Chem. 2026 Jun 18;180:110127.
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