Chemical Structure : LY2183240
CAS No.: 874902-19-9
Catalog No.: PC-42721Not For Human Use, Lab Use Only.
A highly potent blocker of anandamide uptake with IC50 of 270 pM in cellular assay.
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50 mg | $220 | In stock | |
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A highly potent blocker of anandamide uptake with IC50 of 270 pM in cellular assay; inhibits the putative endocannabinoid (EC) transporter, and disrupts the cellular uptake of the lipid EC anandamide and promote analgesia in vivo; proved to be a potent, covalent inhibitor of EC-degrading enzyme FAAH (IC50=12.4 nM) and and several other serine hydrolases in vivo (MAGL, α/β-hydrolase 6, KIAA1363).
M.Wt | 307.3498 | |
Formula | C17H17N5O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1H-Tetrazole-1-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl- |
1. Moore SA, et al. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17852-7.
2. Alexander JP, et al. J Am Chem Soc. 2006 Aug 2;128(30):9699-704.
3. Powers MS, et al. Psychopharmacology (Berl). 2010 Dec;212(4):571-83.
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