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LY2318912

Chemical Structure : LY2318912

CAS No.: 874902-18-8

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LY2318912 (LY 2318912)

Catalog No.: PC-63017Not For Human Use, Lab Use Only.

LY2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd of 7.62 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LY2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd of 7.62 nM.
    LY2318912 elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function in rodents.

    Physicochemical Properties

    M.Wt 441.193
    Formula C12H12IN9O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-[(4-azido-3-iodo-benzoylamino)-methyl]-tetrazole-1-carboxylic acid dimethylamide

    References

    1. Moore SA, et al. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17852-7.

    2. Ortar G, et al. Eur J Med Chem. 2008 Jan;43(1):62-72.

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