Chemical Structure : LY2318912
Catalog No.: PC-63017Not For Human Use, Lab Use Only.
LY2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd of 7.62 nM.
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LY2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd of 7.62 nM.
LY2318912 elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function in rodents.
M.Wt | 441.193 | |
Formula | C12H12IN9O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Moore SA, et al. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17852-7.
2. Ortar G, et al. Eur J Med Chem. 2008 Jan;43(1):62-72.
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