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Chemical Structure : LY2603618
CAS No.: 911222-45-2
Catalog No.: PC-44037Not For Human Use, Lab Use Only.
Rabusertib (LY2603618) is a potent and selective small molecule inhibitor of Chk1 (IC50= 7 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Rabusertib (LY2603618) is a potent and selective small molecule inhibitor of Chk1 (IC50= 7 nM).
Rabusertib (LY2603618) promotes impaired DNA synthesis and elevates H2A.X phosphorylation indicative of DNA damage and premature entry into mitosis.
| M.Wt | 436.303 | |
| Formula | C18H22BrN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 29.5 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)- |
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1. King C, et al. Invest New Drugs. 2014 Apr;32(2):213-26.
2. Emiliano Calvo1, et al. Mol Cancer Ther, 2011, A94.
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