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Chemical Structure : LY2886721
CAS No.: 1262036-50-9
Catalog No.: PC-43420Not For Human Use, Lab Use Only.
LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases.
LY2886721 produces a concentration-dependent decrease in Aβ1-40 and Aβ1-42 production in HEK293Swe cells (EC50s=10 nM).
LY2886721 demonstrates robust in vivo amyloid β lowering effect in nonclinical animal models, shows similar potent and persistent amyloid β lowering was observed in plasma and lumbar in clinical trials.
| M.Wt | 390.407 | |
| Formula | C18H16F2N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
2-Pyridinecarboxamide, N-[3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro- |
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1. Lahiri DK, et al. Alzheimers Dement. 2014 Oct;10(5 Suppl):S411-9.
2. May PC, et al. J Neurosci. 2015 Jan 21;35(3):1199-210.
3. Kumar D, et al. Eur J Med Chem. 2018 Mar 25;148:436-452.
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