LY2955303 | RARγ antagonist | Probechem Biochemicals

Chemical Structure : LY2955303

CAS No.: 1433497-19-8

LY2955303 (LY-2955303)

Catalog No.: PC-62836Not For Human Use, Lab Use Only.

LY2955303 is a potent and selective RARγ antagonist with binding Ki of 1.09 nM, displays >1000-fold selectivity against RARα and RARβ.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$348	In stock
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Biological Activity

LY2955303 is a potent and selective RARγ antagonist with binding Ki of 1.09 nM, displays >1000-fold selectivity against RARα and RARβ.
LY2955303 demonstrates good pharmacokinetic properties and efficacious in the MIA model of osteoarthritis-like joint pain.

Physicochemical Properties

M.Wt	578.76
Formula	C36H42N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid

References

1. Hughes NE, et al. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-7.

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LY2955303 (LY-2955303)

Biological Activity

Physicochemical Properties

References

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