LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively.
LY3020371 exhibits little to no agonist or antagonist activity against mGlu1/4/5/6/7/8 (>1 uM potenct).
LY3020371 potently blocks mGlu2/3 agonist (DCG-IV)-inhibited, forskolin-stimulated cAMP formation with IC50 of 16.2 nM, blocks agonist-suppressed spontaneous Ca2+ oscillations (IC50= 34 nM) and in an intact hippocampal slice preparation (IC50= 46 nM).
LY3020371 exerts an antidepressant-like signature in vivo.
