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Chemical Structure : LY3020371 hydrochloride
Catalog No.: PC-60730Not For Human Use, Lab Use Only.
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively.
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LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively.
LY3020371 exhibits little to no agonist or antagonist activity against mGlu1/4/5/6/7/8 (>1 uM potenct).
LY3020371 potently blocks mGlu2/3 agonist (DCG-IV)-inhibited, forskolin-stimulated cAMP formation with IC50 of 16.2 nM, blocks agonist-suppressed spontaneous Ca2+ oscillations (IC50= 34 nM) and in an intact hippocampal slice preparation (IC50= 46 nM).
LY3020371 exerts an antidepressant-like signature in vivo.
| M.Wt | 395.802 | |
| Formula | C15H16ClF2NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chappell MD, et al. J Med Chem. 2016 Dec 22;59(24):10974-10993.
2. Witkin JM, et al. Neuropharmacology. 2017 Mar 15;115:100-114.
3. Witkin JM, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):68-86.
4. Witkin JM, et al. Pharmacol Biochem Behav. 2017 Apr;155:43-55.
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