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LY3027788

Chemical Structure : LY3027788

CAS No.: 1377615-76-3

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LY3027788 (LY-3027788, LY 3027788)

Catalog No.: PC-60731Not For Human Use, Lab Use Only.

LY3027788 is an orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LY3027788 is an orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively.
    LY3027788 augments the antidepressant-like effects of fluoxetine or citalopram without altering plasma or brain levels of these compounds.

    Physicochemical Properties

    M.Wt 591.576
    Formula C25H31F2NO11S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    bis(((isopropoxycarbonyl)oxy)-methyl) (1S,2R,3S,4S,5R,6R)-2-amino-3-(((3,4-difluorophenyl)thio)methyl)-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylate

    References

    1. Witkin JM, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):68-86.

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