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Chemical Structure : LY3154207
CAS No.: 1638667-79-4
Catalog No.: PC-73068Not For Human Use, Lab Use Only.
LY3154207 (Mevidalen, LY-3154207) is a potent, and subtype selective human dopamine D1 positive allosteric modulator (PAM) with EC50 of 3.0 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $188 | In stock | |
| 5 mg | $368 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $988 | In stock | |
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| 100 mg | Get quote |
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LY3154207 (Mevidalen, LY-3154207) is a potent, and subtype selective human dopamine D1 positive allosteric modulator (PAM) with EC50 of 3.0 nM.
LY3154207 displays exquisite selectivity over the human D5 receptor subtype (EC50>10 uM), and 14 other GPCRs, including D2, β1, β2, and 5HT6 receptors.
Mevidalen enhanced wakefulness (latency to fall asleep) in the hD1 mouse in a dose dependent [3-100 mg/kg, orally (PO)] fashion.
Mevidalen promoted wakefulness in mice after prior sleep deprivation and delayed sleep onset by 5.5- and 15.2-fold compared with vehicle-treated animals.
Mevidalen demonstrated a dose-dependent increase in latency to sleep onset in human clinical investigations.
| M.Wt | 450.4 | |
| Formula | C24H29Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2,6-dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one |
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1. Hao J, et al. J Med Chem. 2019 Oct 10;62(19):8711-8732.
2. McCarthy AP, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):143-152.
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