LY3154885 |CAS:2379422-72-5 Probechem Biochemicals

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Chemical Structure : LY3154885

LY3154885 (LY 3154885)

Catalog No.: PC-38113Not For Human Use, Lab Use Only.

LY 3154885 is a potent dopamine D1 receptor positive allosteric modulator (PAM) with EC50 of 11.7 nM.

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Biological Activity

LY 3154885 is a potent dopamine D1 receptor positive allosteric modulator (PAM) with EC50 of 11.7 nM.
LY 3154885 displays reduced the CYP3A4-mediated victim drug-drug interactions (DDI) risk.
LY 3154885 possesses similar in vitro and in vivo pharmacologic properties as Mevidalen (LY 3154207), but is metabolized mainly by UGT.

Physicochemical Properties

M.Wt	444.356
Formula	C23H23Cl2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

References

1. Junliang Hao, et al. J Med Chem. 2022 Mar 10;65(5):3786-3797.

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LY3154885 (LY 3154885)

Biological Activity

Physicochemical Properties

References

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