LY341495 (LY-341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively.
LY341495 shows less effectively blocks mGluR8 and mGluR7 (IC50=173 and 990 nM) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 uM).
LY341495 penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.
