Catalog No.: PC-63532Not For Human Use, Lab Use Only.
Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM.
Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM.
LYC-55716 displays high selectivity over other NRs, including RORα and RORβ (EC50>10 uM).
LYC-55716 modulates expression of genes that promote immune responses, reduces PD-1 expression in vitro and in vivo after adoptive cell transfer, relieves PD-1/PD-L1 inhibition of proliferation and IFNγ.|
LYC-55716 significantly augments anti-tumor activity of doxorubicin, results in immune-dependent decreased tumor growth and enhanced survival in preclinical models of cancer.
