Chemical Structure : LZK PROTAC-21A
CAS No.:
2763268-64-8
LZK PROTAC-21A
Catalog No.: PC-23565Not For Human Use, Lab Use Only.
LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM.
PROTAC-21A reduces LZK abundance through a mechanism that involved the ubiquitin-like molecule NEDD8 (Figure 6A) and the proteasome.
PROTAC-21A is selective for DLK/LZK against a broad panel of >450 kinases.
PROTAC-21A induces proteasome-mediated degradation of LZK, targets c-MYC and GOF-p53, and decreases HNSCC viability.
Physicochemical Properties
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M.Wt
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967.19
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Formula
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C51H64F2N10O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-1-((S)-2-(8-(4-(2-((4-cyanopyridin-2-yl)amino)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)piperidin-1-yl)-8-oxooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
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References
1. Funk AL, et al. bioRxiv [Preprint]. 2024 Nov 20:2024.11.19.623840.
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