Chemical Structure : Lanperisone
CAS No.:
116287-14-0
Lanperisone
(NK 433)
Catalog No.: PC-62036Not For Human Use, Lab Use Only.
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion; shows potent and selective activity against K-rasG12D MEFs with IC50 of 4 uM in the CTG viability assay; causes a large population of cells with sub-2N DNA content, induces oxidative stress, but not in wild-type MEFs; suppresses the growth of K-ras-driven tumors without overt toxicity in mice; orally bioactive.
Physicochemical Properties
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M.Wt
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285.305
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Formula
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C15H18F3NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R)-2-methyl-3-pyrrolidin-1-yl-1-[4-(trifluoromethyl)phenyl]propan-1-one
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References
1. Shaw AT, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8.
2. Sakitama K, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):175-87.
3. Glasauer A, et al. Biochem Pharmacol. 2014 Nov 1;92(1):90-101.
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