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Chemical Structure : Laquinimod
CAS No.: 248281-84-7
Catalog No.: PC-43319Not For Human Use, Lab Use Only.
Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).
Laquinimod (ABR-215062) dose-dependently reduces the incidence of EAN, ameliorated clinical signs and inhibited P0 peptide 180-199-specific T cell responses as well as also the decreased inflammation and demyelination in the peripheral nerves.
Laquinimod (ABR-215062) shows improved potency and superior toxicological profile compared to the lead compound Roquinimex (Linomide).
| M.Wt | 356.8029 | |
| Formula | C19H17ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl- |
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1. Zou LP, et al. Neuropharmacology. 2002 Apr;42(5):731-9.
2. Brunmark C, et al. J Neuroimmunol. 2002 Sep;130(1-2):163-72.
3. Jönsson S, et al. J Med Chem. 2004 Apr 8;47(8):2075-88.
4. Polman C, et al. Neurology. 2005 Mar 22;64(6):987-91.
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