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Laquinimod

Chemical Structure : Laquinimod

CAS No.: 248281-84-7

Laquinimod (ABR-215062, ABR215062)

Catalog No.: PC-43319Not For Human Use, Lab Use Only.

Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).

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Biological Activity

Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).
Laquinimod (ABR-215062) dose-dependently reduces the incidence of EAN, ameliorated clinical signs and inhibited P0 peptide 180-199-specific T cell responses as well as also the decreased inflammation and demyelination in the peripheral nerves.
Laquinimod (ABR-215062) shows improved potency and superior toxicological profile compared to the lead compound Roquinimex (Linomide).

Physicochemical Properties

M.Wt 356.8029
Formula C19H17ClN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-

References

1. Zou LP, et al. Neuropharmacology. 2002 Apr;42(5):731-9.

2. Brunmark C, et al. J Neuroimmunol. 2002 Sep;130(1-2):163-72.

3. Jönsson S, et al. J Med Chem. 2004 Apr 8;47(8):2075-88.

4. Polman C, et al. Neurology. 2005 Mar 22;64(6):987-91.

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