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Larixyl acetate

Chemical Structure : Larixyl acetate

CAS No.: 4608-49-5

Larixyl acetate (Larix-6-yl monoacetate)

Catalog No.: PC-60610Not For Human Use, Lab Use Only.

Larixyl acetate is a potent, selective TRPC6 channel inhibitor with IC50 of 0.1-0.6 uM, 12- and 5-fold selectivity over related TRPC3 and TRPC7.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Larixyl acetate is a potent, selective TRPC6 channel inhibitor with IC50 of 0.1-0.6 uM, 12- and 5-fold selectivity over related TRPC3 and TRPC7.
Larixyl acetate inhibits native TRPC6-like [Ca(2+)]i signals in diacylglycerol-stimulated rat pulmonary artery smooth muscle cells.
Larixyl acetate prevents acute hypoxia-induced vasoconstriction in isolated mouse lungs.

Physicochemical Properties

M.Wt 348.527
Formula C22H36O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,4S,4aR,8aS)-4-((S)-3-hydroxy-3-methylpent-4-en-1-yl)-4a,8,8-trimethyl-3-methylenedecahydronaphthalen-1-yl acetate

References

1. Urban N, et al. Mol Pharmacol. 2016 Jan;89(1):197-213.

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