Lavengratinib (ABSK061) | FGFR2/3 inhibitor

Chemical Structure : Lavengratinib

Lavengratinib (ABSK061, ABSK-061)

Catalog No.: PC-27469Not For Human Use, Lab Use Only.

Lavengratinib (ABSK061) is a potent, highly selective oral FGFR2/3 inhibitor, including secondary FGFR2/3 kinase domain mutations as well as off-target alterations in RTK/RAS and DDR pathways.

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Biological Activity

Lavengratinib (ABSK061) is a potent, highly selective oral FGFR2/3 inhibitor, including secondary FGFR2/3 kinase domain mutations as well as off-target alterations in RTK/RAS and DDR pathways.

Physicochemical Properties

M.Wt	544.43
Formula	C26H27Cl2N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methyl-7-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-2(1H)-one

References

1. Patent WO2020052349 A1 2020-03-19.

2. Yue Wang, et al. Cancer Res (2026) 86 (7_Supplement): 5319.

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Lavengratinib (ABSK061, ABSK-061)

Biological Activity

Physicochemical Properties

References

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