Lenabasum |CAS:137945-48-3 Probechem Biochemicals

Chemical Structure : Lenabasum

Lenabasum (Ajulemic acid, IP-751, Anabasum)

Catalog No.: PC-61381Not For Human Use, Lab Use Only.

Lenabasum (Ajulemic acid, IP-751, Anabasum) is a synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ.

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Biological Activity

Lenabasum (Ajulemic acid, IP-751, Anabasum) is a synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ.
Lenabasum produces significant antitumor activity and effects its actions primarily via CB(2) receptors.
Lenabasum inhibits interleukin-8 promoter activity in a PPARgamma-dependent manner; significantly suppresses CYP-induced urinary frequency in rats at 10 mg/kg.

Physicochemical Properties

M.Wt	400.559
Formula	C25H36O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran-9-carboxylic acid

References

1. Recht LD, et al. Biochem Pharmacol. 2001 Sep 15;62(6):755-63.

2. Ambrosio AL, et al. J Biol Chem. 2007 Jun 22;282(25):18625-33.

3. Johnson DR, et al. J Cell Biochem. 2007 Jan 1;100(1):184-90.

4. Hiragata S, et al. Urology. 2007 Jul;70(1):202-8.

Lenabasum (Ajulemic acid, IP-751, Anabasum)

Biological Activity

Physicochemical Properties

References

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