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Lenvatinib

Chemical Structure : Lenvatinib

CAS No.: 417716-92-8

Lenvatinib (E7080, E-7080)

Catalog No.: PC-42762Not For Human Use, Lab Use Only.

Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays.
Lenvatinib (E7080) also inhibits PDGFR, Kit with IC50< 100 nM.
Lenvatinib (E7080) suppresses the phosphorylation of VEGF receptor-2 and FGF receptor 1 and inhibits proliferation of endothelial cellin vitro; orally active.

Physicochemical Properties

M.Wt 426.853
Formula C21H19ClN4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-

References

1. Matsui J, et al. Int J Cancer. 2008 Feb 1;122(3):664-71.

2. Matsui J, et al. Clin Cancer Res. 2008 Sep 1;14(17):5459-65.

3. Ikuta K, et al. Clin Cancer Res. 2009 Dec 1;15(23):7229-37.

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