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Leriglitazone

Chemical Structure : Leriglitazone

CAS No.: 146062-44-4

Leriglitazone (MIN-102, MIN102)

Catalog No.: PC-49255Not For Human Use, Lab Use Only.

MIN-102 (Leriglitazone) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with a potential best-in-class profile indicated for CNS diseases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MIN-102 (Leriglitazone) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with a potential best-in-class profile indicated for CNS diseases.
    MIN-102 (Leriglitazone) increases frataxin levels and mitochondrial markers in FRDA models.
    MIN-102 (Leriglitazone) protects from neurodegeneration by improving mitochondrial function.
    MIN-102 (Leriglitazone) prevents lipid droplets formation in frataxin-deficient cardiomyocytes.
    MIN-102 (Leriglitazone) rescues the motor function deficit of the YG8sR mice.
    MIN-102 (Leriglitazone) emerges as a potential therapeutic agent for Friedreich Ataxia.

    Physicochemical Properties

    M.Wt 372.439
    Formula C19H20N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-[[4-[2-[5-(1-Hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

    References

    1. Laura Rodríguez-Pascau, et al. Neurobiol Dis. 2021 Jan;148:105162.

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