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Leriglitazone

Chemical Structure : Leriglitazone

CAS No.: 146062-44-4

Leriglitazone (MIN-102, MIN102)

Catalog No.: PC-49255Not For Human Use, Lab Use Only.

Leriglitazone (MIN-102) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with EC50 of 9 uM, shows potential best-in-class profile indicated for CNS diseases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Leriglitazone (MIN-102) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with EC50 of 9 uM, shows potential best-in-class profile indicated for CNS diseases.
Leriglitazone (MIN-102) increases frataxin levels and mitochondrial markers in FRDA models.
Leriglitazone (MIN-102) protects from neurodegeneration by improving mitochondrial function.
Leriglitazone (MIN-102) prevents lipid droplets formation in frataxin-deficient cardiomyocytes.
Leriglitazone (MIN-102) rescues the motor function deficit of the YG8sR mice.
Leriglitazone (MIN-102) emerges as a potential therapeutic agent for Friedreich Ataxia.

Physicochemical Properties

M.Wt 372.439
Formula C19H20N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-[[4-[2-[5-(1-Hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

References

1. Laura Rodríguez-Pascau, et al. Neurobiol Dis. 2021 Jan;148:105162.

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