Chemical Structure : Leriglitazone
CAS No.: 146062-44-4
Catalog No.: PC-49255Not For Human Use, Lab Use Only.
Leriglitazone (MIN-102) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with EC50 of 9 uM, shows potential best-in-class profile indicated for CNS diseases.
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Leriglitazone (MIN-102) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with EC50 of 9 uM, shows potential best-in-class profile indicated for CNS diseases.
Leriglitazone (MIN-102) increases frataxin levels and mitochondrial markers in FRDA models.
Leriglitazone (MIN-102) protects from neurodegeneration by improving mitochondrial function.
Leriglitazone (MIN-102) prevents lipid droplets formation in frataxin-deficient cardiomyocytes.
Leriglitazone (MIN-102) rescues the motor function deficit of the YG8sR mice.
Leriglitazone (MIN-102) emerges as a potential therapeutic agent for Friedreich Ataxia.
| M.Wt | 372.439 | |
| Formula | C19H20N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[[4-[2-[5-(1-Hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
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1. Laura Rodríguez-Pascau, et al. Neurobiol Dis. 2021 Jan;148:105162.

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