Leucettamine B |CAS:147395-96-8 Probechem Biochemicals

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Chemical Structure : Leucettamine B

Leucettamine B

Catalog No.: PC-63478Not For Human Use, Lab Use Only.

Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM)..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).

Physicochemical Properties

M.Wt	245.238
Formula	C12H11N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5Z)-2-amino-5-(1,3-benzodioxol-5-ylmethylidene)-3-methylimidazol-4-one

References

1. Chan GW, et al. J Nat Prod. 1993 Jan;56(1):116-21.

2. Debdab M, et al. J Med Chem. 2011 Jun 23;54(12):4172-86.

3. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30.

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Leucettamine B

Biological Activity

Physicochemical Properties

References

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