Leucettinib-92

Chemical Structure : Leucettinib-92

Catalog No.: PC-20985Not For Human Use, Lab Use Only.

Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.

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Biological Activity

Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.
Leucettinib-92 preferably targets CLK1, CLK2, CLK4, DYRK1A and DYRK1B on the Eurofins DiscovRx KinomeScan selectivity panel (468 kinases) at 1 uM.
Leucettinib-92 can penetrate cells and inhibits DYRK1A at low concentrations (from 0.1–0.3 μM) in cell models.

Physicochemical Properties

M.Wt	378.49
Formula	C21H22N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1NC(NC23CC4CC(C3)CC(C4)C2)=N/C1=C\C5=CC=C6N=CSC6=C5

References

1. Emmanuel Deau, et al. J Med Chem. 2023 Jul 24. doi: 10.1021/acs.jmedchem.3c00884.

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Leucettinib-92

Biological Activity

Physicochemical Properties

References

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