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Chemical Structure : Leucettinib-92
Catalog No.: PC-20985Not For Human Use, Lab Use Only.
Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.
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Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.
Leucettinib-92 preferably targets CLK1, CLK2, CLK4, DYRK1A and DYRK1B on the Eurofins DiscovRx KinomeScan selectivity panel (468 kinases) at 1 uM.
Leucettinib-92 can penetrate cells and inhibits DYRK1A at low concentrations (from 0.1–0.3 μM) in cell models.
| M.Wt | 378.49 | |
| Formula | C21H22N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emmanuel Deau, et al. J Med Chem. 2023 Jul 24. doi: 10.1021/acs.jmedchem.3c00884.
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