Licancopan fumarate | Factor B inhibitor

Chemical Structure : Licancopan fumarate

Licancopan fumarate (HRS-5965, HRS5965)

Catalog No.: PC-28511Not For Human Use, Lab Use Only.

Licancopan fumarate (HRS-5965) is a potent, selective and orally active complement factor (Factor B) inhibitor, disrupts the formation of C3 convertases within the alternative pathway, thereby halting C3 cleavage and downstream complement activation.

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Biological Activity

Physicochemical Properties

M.Wt	564.64
Formula	C31H36N2O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((1S,3S,5R)-3-ethoxy-8-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)-8-azabicyclo[3.2.1]octan-1-yl)benzoic acid fumarate

References

1. Patent WO2022143845 A1.

2. Xu Y, et al. Med. 2025 Aug 8;6(8):100698.

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Licancopan fumarate (HRS-5965, HRS5965)

Biological Activity

Physicochemical Properties

References

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