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Licochalcone E

Chemical Structure : Licochalcone E

CAS No.: 864232-34-8

Licochalcone E (LicoE)

Catalog No.: PC-23581Not For Human Use, Lab Use Only.

Licochalcone E (LicoE) is a glycyrrhiza-inflata-derived chalcone, exhibits potent anti-inflammatory properties inhibits Aβ1-42 aggregation and activates Nrf2, also inhibits pancreatic lipase (PL) with IC50 of 5.8 uM.

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Biological Activity

Licochalcone E (LicoE) is a glycyrrhiza-inflata-derived chalcone, exhibits potent anti-inflammatory properties inhibits Aβ1-42 aggregation and activates Nrf2, also inhibits pancreatic lipase (PL) with IC50 of 5.8 uM.
Licochalcone E displays high efficiency against methicillin-resistant Staphylococcus aureus (MRSA).
Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells.
Licochalcone E suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.
Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway.

Physicochemical Properties

M.Wt 338.40
Formula C21H22O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S,E)-3-(4-Hydroxy-2-methoxy-5-(3-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

References

1. Kim SS, et al. J Nutr Biochem. 2012 Oct;23(10):1314-23.

2. Zhou T, et al. J Microbiol Biotechnol. 2012 Jun;22(6):800-5.

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