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Licoflavone A

Chemical Structure : Licoflavone A

CAS No.: 61153-77-3

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Licoflavone A

Catalog No.: PC-25608Not For Human Use, Lab Use Only.

Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B) with IC50 of 54.5 uM, also has anti-gastric cancer potency in vitro and in vivo, affects the proliferation, cycle, apoptosis, migration, invasion, and EMT by targeting VEGFR-2 and blocks the PI3K/AKT and MEK/ERK signaling pathways.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B) with IC50 of 54.5 uM, also has anti-gastric cancer potency in vitro and in vivo, affects the proliferation, cycle, apoptosis, migration, invasion, and EMT by targeting VEGFR-2 and blocks the PI3K/AKT and MEK/ERK signaling pathways.

Physicochemical Properties

M.Wt 322.36
Formula C20H18O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

References

1. Li S, et al. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401.

2. Hongxia G, et al. J Oncol. 2022 Apr 25;2022:5497991.

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