Linerixibat (GSK2330672) | ASBT inhibitor

Chemical Structure : Linerixibat

CAS No.: 1345982-69-5

Linerixibat (GSK-2330672, GSK2330672)

Catalog No.: PC-61384Not For Human Use, Lab Use Only.

Linerixibat (GSK2330672) is a highly potent, selective, ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor with IC50 of 2.1/1.9 nM for mouse/rat ASBT, respectively.

Packing	Price	Stock
5 mg	$238	In stock
10 mg	$378	In stock
25 mg	$588	In stock
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Biological Activity

Linerixibat (GSK2330672) is a highly potent, selective, ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor with IC50 of 2.1/1.9 nM for mouse/rat ASBT, respectively.
Linerixibat (GSK2330672 lowers glucose in an animal model of type 2 diabetes, shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.

Physicochemical Properties

M.Wt	546.679
Formula	C28H38N2O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[[(3R,5R)-3-Butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl]methyl]amino]pentanedioic acid

References

1. Wu Y, et al. J Med Chem. 2013 Jun 27;56(12):5094-114.

2. Nunez DJ, et al. Diabetes Obes Metab. 2016 Jul;18(7):654-62.

3. Hegade VS, et al. Lancet. 2017 Mar 18;389(10074):1114-1123.

Linerixibat (GSK-2330672, GSK2330672)

Biological Activity

Physicochemical Properties

References

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