You are here:Home-Chemical Inhibitors & Agonists-GPCR-GNRH Receptor-Linzagolix
Linzagolix

Chemical Structure : Linzagolix

CAS No.: 935283-04-8

Linzagolix (KLH-2109, OBE-2109, KLH2109, OBE2109)

Catalog No.: PC-61385Not For Human Use, Lab Use Only.

Linzagolix (KLH-2109, OBE-2109) is a potent, non-peptide, and orally active gonadotrophin releasing hormone (GnRH) antagonist, inhibits GnRH-stimulated Ca2+ flux with IC50 of 36.7 nM (human GnRH receptor).

Packing Price Stock Quantity
5 mg $78 In stock
10 mg $118 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Linzagolix (KLH-2109, OBE-2109) is a potent, non-peptide, and orally active gonadotrophin releasing hormone (GnRH) antagonist, inhibits GnRH-stimulated Ca2+ flux with IC50 of 36.7 nM (human GnRH receptor).
Linzagolix shows 12-fold lower potency for the monkey GnRH receptor.
Linzagolix selectively binds to the GnRH receptor and inhibits GnRH-stimulated signalling, in a manner comparable to cetrorelix, a peptide GnRH antagonist.
Linzagolix suppressed the serum luteinizing hormone concentration at doses over 1 mg/kg in ovariectomized monkeys.
Linzagolix suppressed hormone surges and ceased or prolonged menstrual cycles in intact female monkeys.

Physicochemical Properties

M.Wt 508.424
Formula C22H15F3N2O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-{5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl}-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid

References

1. Tezuka M, et al. Clin Exp Pharmacol Physiol. 2022 Oct;49(10):1082-1093.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: