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Lometrexol

Chemical Structure : Lometrexol

CAS No.: 106400-81-1

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Lometrexol (DDATHF)

Catalog No.: PC-26409Not For Human Use, Lab Use Only.

Lometrexol (DDATHF) is an antipurine antifolate and inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), also inhibits serine hydroxymethyltransferase (SHMT) with ITC KD of 2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lometrexol (DDATHF) is an antipurine antifolate and inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), also inhibits serine hydroxymethyltransferase (SHMT) with ITC KD of 2 uM.

Physicochemical Properties

M.Wt 443.46
Formula C21H25N5O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(2-((R)-2-Amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzoyl)-L-glutamic acid

References

1. Taylor EC, et al. J Med Chem. 1985 Jul;28(7):914-21.

2. Paiardini A, et al. ChemMedChem. 2015 Mar;10(3):490-7.

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