Catalog No.: PC-21769Not For Human Use, Lab Use Only.
Lonafarnib (SCH 66336) is a potent, orally bioavailable farnesyl protein transferase (FTase, farnesyltransferase) inhibitor with IC50 of 1.9 nM for H-Ras processing in whole cells.
Lonafarnib (SCH 66336) is a potent, orally bioavailable farnesyl protein transferase (FTase, farnesyltransferase) inhibitor with IC50 of 1.9 nM for H-Ras processing in whole cells.
Lonafarnib (SCH 66336) inhibits K-ras and N-ras with IC50 of 5.2 nM and 2.8 nM, respectively. blocks the trans formed growth properties of fibroblasts and human tumor cell lines expressing activated Ki-Ras proteins.
Lonafarnib (SCH 66336) inhibits tumor growth in nude mice treated with cells that contained either K-ras mutations (MIA PACA-2, human pancreatic cancer, and HCT-116, human colon cancer) or H-ras mutations (transformed mouse fibroblast, NIH3T3-CVLS), in a dose-dependent manner.
Lonafarnib (SCH 66336) exhibits good oral pharmacokinetics in monkeys and showed good oral efficacy as an antitumor agent in mice.
