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Losartan

Chemical Structure : Losartan

CAS No.: 114798-26-4

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Losartan (DuP-753)

Catalog No.: PC-45316Not For Human Use, Lab Use Only.

Losartan (DuP-753) is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension), also inhibits PAX8 expression and function.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Losartan (DuP-753) is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension), also inhibits PAX8 expression and function.

Physicochemical Properties

M.Wt 422.9106
Formula C22H23ClN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

References

1. Burnier, M. Circulation, 2001. 103(6): p. 904-12.

2. Ashry, O., et al. Respir Physiol Neurobiol, 2014.

3. Habashi, J.P., et al. Science, 2006. 312(5770): p. 117-21.

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