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Chemical Structure : Lurasidone hydrochloride
CAS No.: 367514-88-3
Catalog No.: PC-21084Not For Human Use, Lab Use Only.
Lurasidone hydrochloride (SM-13496) is an atypical antipsychotic compound with potent dopamine D2 (Ki =1.68 nM) and serotonin 5-HT2A (Ki=2.03 nM) receptor-blocking activities.
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|---|---|---|---|
| 100 mg | $198 | In stock | |
| 200 mg | $298 | In stock | |
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Lurasidone hydrochloride (SM-13496) is an atypical antipsychotic compound with potent dopamine D2 (Ki =1.68 nM) and serotonin 5-HT2A (Ki=2.03 nM) receptor-blocking activities.
Lurasidone (SM-13496) also has high affinities for serotonin 5-HT1A (Ki = 6.75 nM), 5-HT7 receptors (Ki = 0.495 nM), and α2C adrenoceptor (Ki = 10.8 nM), but only weak or negligible interactions with serotonin 5-HT2C, histamine H1, acetylcholine M1 receptors, and α1 adrenoceptor.
Lurasidone (SM-13496) significantly and dose-dependently reversed the MK-801-induced impairment of the passive-avoidance response.
Lurasidone (SM-13496) is superior to other antipsychotics in improving the MK-801-induced memory impairment.
| M.Wt | 529.14 | |
| Formula | C28H37ClN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride |
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1. Ishiyama T, et al. Eur J Pharmacol. 2007 Oct 31;572(2-3):160-70.
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