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Lurasidone hydrochloride

Chemical Structure : Lurasidone hydrochloride

CAS No.: 367514-88-3

Lurasidone hydrochloride (SM-13496, SM13496)

Catalog No.: PC-21084Not For Human Use, Lab Use Only.

Lurasidone hydrochloride (SM-13496) is an atypical antipsychotic compound with potent dopamine D2 (Ki =1.68 nM) and serotonin 5-HT2A (Ki=2.03 nM) receptor-blocking activities.

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Biological Activity

Lurasidone hydrochloride (SM-13496) is an atypical antipsychotic compound with potent dopamine D2 (Ki =1.68 nM) and serotonin 5-HT2A (Ki=2.03 nM) receptor-blocking activities.
Lurasidone (SM-13496) also has high affinities for serotonin 5-HT1A (Ki = 6.75 nM), 5-HT7 receptors (Ki = 0.495 nM), and α2C adrenoceptor (Ki = 10.8 nM), but only weak or negligible interactions with serotonin 5-HT2C, histamine H1, acetylcholine M1 receptors, and α1 adrenoceptor.
Lurasidone (SM-13496) significantly and dose-dependently reversed the MK-801-induced impairment of the passive-avoidance response.
Lurasidone (SM-13496) is superior to other antipsychotics in improving the MK-801-induced memory impairment.

Physicochemical Properties

M.Wt 529.14
Formula C28H37ClN4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride

References

1. Ishiyama T, et al. Eur J Pharmacol. 2007 Oct 31;572(2-3):160-70.

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