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Luvadaxistat

Chemical Structure : Luvadaxistat

CAS No.: 1425511-32-5

Luvadaxistat (TAK-831, NBI-1065844)

Catalog No.: PC-20902Not For Human Use, Lab Use Only.

TAK-831 (Luvadaxistat, NBI-1065844) is a highly potent, selective D-amino acid oxidase (DAAO) inhibitor with IC50 of 14 nM against human recombinant DAAO enzyme.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TAK-831 (Luvadaxistat, NBI-1065844) is a highly potent, selective D-amino acid oxidase (DAAO) inhibitor with IC50 of 14 nM against human recombinant DAAO enzyme.
TAK-831 (Luvadaxistat) inhibits the formation of H2O2, the co-product of D-serine catalysis, with an IC50 of 12 nM, in a cellular assay using CHO cells expressing recombinant human DAAO.
TAK-831 (Luvadaxistat) inhibits H2O2 formation with IC50 of 5.1 nM in CHO cells expressing recombinant mouse DAAO.
TAK-831 (Luvadaxistat) shows very little off-target activity when profiled in a comprehensive selectivity panel of enzyme and radioactivity binding.
TAK-831 (Luvadaxistat) caused a dose- and exposure-dependent blockade of PGM019260 binding in the cerebellum with ED50 of 0.93 mg/kg in enzyme occupancy studies in mice.
TAK-831 (Luvadaxistat) (3 mg/kg p.o.) significantly reverses a poly(I:C)-induced deficit, improves social behavior in the SI test in BALB/c animals.

Physicochemical Properties

M.Wt 284.24
Formula C13H11F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-hydroxy-6-(4-(trifluoromethyl)phenethyl)pyridazin-3(2H)-one

References

1. Fradley R, et al. Neurochem Res. 2023 Jun 8. doi: 10.1007/s11064-023-03956-2.

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