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Chemical Structure : M-808
Catalog No.: PC-20564Not For Human Use, Lab Use Only.
M-808 (M808) is a highly potent, selective and covalent inhibitor of menin-MLL interaction with binding IC50 of 2.6 nM, forms a covalent bond with Cys329 in menin.
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M-808 (M808) is a highly potent, selective and covalent inhibitor of menin-MLL interaction with binding IC50 of 2.6 nM, forms a covalent bond with Cys329 in menin.
M-808 effectively inhibits leukemia cell growth of MV4;11 and MOLM13 cell lines carrying MLL fusion with IC50 of 1 and 4 nM, respectively.
M-808 (25 mg/kg, i.v. qD) exhibits partial tumor regression in the MV4;11 leukemia xenograft tumor model in mice, suppresses expression of HOXA9 and MEIS1 genes in MV4;11 xenograft tumors.
| M.Wt | 819.09 | |
| Formula | C45H63FN6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu S, et al. J Med Chem. 2020 May 14;63(9):4997-5010.
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