Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-M-808
M-808

Chemical Structure : M-808

CAS No.: 2377335-74-3

Add to Favorites

M-808 (M808)

Catalog No.: PC-20564Not For Human Use, Lab Use Only.

M-808 (M808) is a highly potent, selective and covalent inhibitor of menin-MLL interaction with binding IC50 of 2.6 nM, forms a covalent bond with Cys329 in menin.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

M-808 (M808) is a highly potent, selective and covalent inhibitor of menin-MLL interaction with binding IC50 of 2.6 nM, forms a covalent bond with Cys329 in menin.
M-808 effectively inhibits leukemia cell growth of MV4;11 and MOLM13 cell lines carrying MLL fusion with IC50 of 1 and 4 nM, respectively.
M-808 (25 mg/kg, i.v. qD) exhibits partial tumor regression in the MV4;11 leukemia xenograft tumor model in mice, suppresses expression of HOXA9 and MEIS1 genes in MV4;11 xenograft tumors.

Physicochemical Properties

M.Wt 819.09
Formula C45H63FN6O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(OC)N[C@@H]1[C@@H]([C@@](C2CCN(CC3CN(C4=CC=C(S(=O)(C5CN(C(/C=C/CN6CCCCC6)=O)C5)=O)C=C4)C3)CC2)(C7=CC=CC(F)=C7)CN8CCC8)CCC1

References

1. Xu S, et al. J Med Chem. 2020 May 14;63(9):4997-5010.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: