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MA-0204

Chemical Structure : MA-0204

CAS No.: 2095128-17-7

MA-0204 (MA0204;MA 0204)

Catalog No.: PC-35702Not For Human Use, Lab Use Only.

MA-0204 (MA0204) is a potent, selective PPARδ modulator with EC50 of 0.4 nM (human PPARδ), dispalys no activity (10,000-fold selectivity) against PPARα and PPARγ.

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Biological Activity

MA-0204 (MA0204) is a potent, selective PPARδ modulator with EC50 of 0.4 nM (human PPARδ), dispalys no activity (10,000-fold selectivity) against PPARα and PPARγ.
MA-0204 exhibits potency for mouse PPARδ and rat PPARδ with EC50 of 7.9 nM and 10 nM, respectively.
MA-0204 also displays high selectivity (EC50 >10 µM) over other nuclear receptors,eg, androgen, progesterone and glucocorticoid receptors.
MA-0204 increases PPARδ target genes ANGPTL4 (angiopoietin like protein 4), CPT1a (carnitine palmytoyltransferase 1a) and PDK4, and improves fatty acid oxidation in vivo in mice and in vitro in patient-derived muscle myoblasts.

Physicochemical Properties

M.Wt 476.496
Formula C25H27F3N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3-methyl-6-(2-((5-methyl-2-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid

References

1. Lagu B, et al. ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.

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