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Chemical Structure : MA-0204
Catalog No.: PC-35702Not For Human Use, Lab Use Only.
MA-0204 (MA0204) is a potent, selective PPARδ modulator with EC50 of 0.4 nM (human PPARδ), dispalys no activity (10,000-fold selectivity) against PPARα and PPARγ.
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MA-0204 (MA0204) is a potent, selective PPARδ modulator with EC50 of 0.4 nM (human PPARδ), dispalys no activity (10,000-fold selectivity) against PPARα and PPARγ; exhibits potency for mouse PPARδ and rat PPARδ with EC50 of 7.9 nM and 10 nM, respectively; also displays high selectivity (EC50 >10 µM) over other nuclear receptors,eg, androgen, progesterone and glucocorticoid receptors; increases PPARδ target genes ANGPTL4 (angiopoietin like protein 4), CPT1a (carnitine palmytoyltransferase 1a) and PDK4, and improves fatty acid oxidation in vivo in mice and in vitro in patient-derived muscle myoblasts.
| M.Wt | 476.496 | |
| Formula | C25H27F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lagu B, et al. ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.
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