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MAC-5576

Chemical Structure : MAC-5576

CAS No.: 219929-01-8

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MAC-5576 (MAC5576, MAC-0005576)

Catalog No.: PC-73340Not For Human Use, Lab Use Only.

MAC-5576 (MAC5576) is a small molecule, covalent inhibitor of coronavirus SARS-CoV 3CLpro with IC50 of 0.5 uM, inhibits SARS-CoV-2 3CL protease with IC50 of 0.093 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MAC-5576 (MAC5576) is a small molecule, covalent inhibitor of coronavirus SARS-CoV 3CLpro with IC50 of 0.5 uM, inhibits SARS-CoV-2 3CL protease with IC50 of 0.093 uM.
    MAC-5576 inhibits Hepatitis A virus (HAV) 3Cpro with IC50 of 0.54 uM.
    MAC-5576 selectively binds to the active site cysteine 145 of the SARS-CoV-2 3CL protease.

    Physicochemical Properties

    M.Wt 239.673
    Formula C10H6ClNO2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloropyridin-3-yl thiophene-2-carboxylate

    References

    1. Jan E Blanchard, et al. Chem Biol. 2004 Oct;11(10):1445-53.

    2. Hengrui Liu, et al. Nat Commun. 2022 Apr 7;13(1):1891.

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