Catalog No.: PC-49167Not For Human Use, Lab Use Only.
MAGLi 432 is a highly selective, potent and reversible monoacylglycerol lipase (MAGL) inhibitor with IC50 of 4.2 and 3.1 nM for human and mouse MAGL enzyme, respectively.
MAGLi 432 is a highly selective, potent and reversible monoacylglycerol lipase (MAGL) inhibitor with IC50 of 4.2 and 3.1 nM for human and mouse MAGL enzyme, respectively.
MAGLi 432 selectively blocks binding of TAMRA-FP to MAGL but not to the active sites of other serine hydrolases in competitive activity based protein profiling (ABPP) assays.
MAGLi 432 inhibits MAGL activity and MAGLi 432 (0.01-10 uM) robustly enhances 2-AG levels in human NVU cells.
MAGLi 432 (1 mg/kg) achieves target occupancy and target engagement in a mouse model of LPS-induced neuroinflammation.
MAGLi 432 treatment after LPS challenge does not ameliorate lipopolysaccharide-induced blood-brain barrier permeability in vivo or reduce the production of pro-inflammatory cytokines in the brain.
